Live NIH Registry Connection

Recruiting Kidney Clinical Trials Explorer

Clinical trials give patients early access to specialist nephrology teams and next-generation kidney therapies before they reach general pharmacies. Use the live explorer below to search actively recruiting studies directly from the U.S. National Library of Medicine (ClinicalTrials.gov API v2).

Browse by Clinical Research Area

Not sure what to search for? Here are the five most active areas of kidney research today, with plain-English explanations and direct links to pre-filtered official registries.

Stages 2, 3a, 3b, and 4

General CKD Progression & Non-Diabetic Kidney Protection

Studies evaluating next-generation SGLT2 combinations, non-steroidal mineralocorticoid blockers, aldosterone synthase inhibitors, and anti-fibrotic therapies designed to slow or halt eGFR decline.

View Recruiting Studies on ClinicalTrials.gov ↗
Stages 1 to 4 with Proteinuria (UACR > 300 mg/g)

IgA Nephropathy (IgAN), FSGS & Glomerular Diseases

Targeted complement pathway inhibitors, APRIL/BAFF blockers, and dual endothelin-angiotensin receptor blockers that stop protein leakage and immune complex deposition without systemic high-dose steroids.

View Recruiting Studies on ClinicalTrials.gov ↗
Stages 1 to 4 with Enlarging Kidney Cysts

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Clinical trials testing novel cyst-slowing compounds, microRNA therapies (such as farabursen), and vasopressin pathway modulators with fewer thirst and urination side effects.

View Recruiting Studies on ClinicalTrials.gov ↗
Patients with APOL1 Risk Variants or Family History

APOL1-Mediated Kidney Disease & Genetic Nephropathies

Precision small-molecule inhibitors (such as inaxaplin and next-generation APOL1 channel blockers) that directly silence the toxic protein pore caused by two APOL1 genetic variants.

View Recruiting Studies on ClinicalTrials.gov ↗
Stage 4, Stage 5, and Dialysis/Transplant Candidates

Cellular Regeneration, Wearable Dialysis & Xenotransplantation

Autologous renal progenitor cell injections (REACT), portable sorbent dialysis devices, and FDA-cleared gene-edited pig kidney transplant clinical trials.

View Recruiting Studies on ClinicalTrials.gov ↗

3 Reassuring Facts About Kidney Clinical Trials

1. You Keep Your Standard Care

Modern kidney trials almost never ask you to stop your proven blood pressure or protective medications. Instead, the study treatment (or placebo) is tested on top of the best existing standard of care.

2. Study Visits & Labs Are Covered

Trial sponsors cover the cost of the investigational medication, specialized lab panels, and study-specific clinic visits, and many studies reimburse travel and parking expenses.

3. Participation Is 100% Voluntary

Signing an informed consent form is not a contract. You have the right to leave a clinical trial at any moment, for any reason, without affecting your regular medical care.